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Technical Data
| Formula | C25H32O2 |
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| Molecular Weight | 364.52 | CAS No. | 152-43-2 | |
| Solubility (25°C)* | In vitro | DMSO | 72 mg/mL (197.52 mM) | |
| Ethanol | 72 mg/mL (197.52 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Quinestrol (Ethinylestradiol 3-cyclopentyl ether, EE2CPE, W-3566) is a synthetic, steroidal estrogen which is used in hormone replacement therapy and occasionally to treat breast cancer and prostate cancer. |
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| In vitro | Quinestrol (17-alpha ethinylestradiol-3-cyclopentyl ether), a derivative of ethinylestradiol, is a long-acting synthetic estrogen. Its estrogenic activity is about 8 to 10 times that of its matrix, and it has strong antifertility effects[1]. |
| In vivo | Animal experiments show that after oral administration, quinestrol is absorbed by the gastrointestinal tract and stored in the adipose tissue; then it is gradually released into the bloodstream at low levels to maintain a long-lasting effective concentration. Male gerbils exposed to quinestrol show a significant decrease in epididymides, seminal vesicles, semen quality, and reproductive rates. Quinestrol treatment causes an imbalance in the oxidation and antioxidant system in blood and testicular tissue. Quinestrol induces ROS and simultaneously reduces antioxidant enzyme activity, leaving germ cells in their oxidation state, which results in spermatogenic cell damage. [1]. |
Protocol (from reference)
| Animal Study:[1] |
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RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.