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Formula | C22H20N4O |
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Molecular Weight | 356.42 | CAS No. | 545380-34-5 | |
Solubility (25°C)* | In vitro | DMSO | 71 mg/mL (199.2 mM) | |
Water | Insoluble | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively. | ||||
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In vitro | EVP4593 inhibits TNF-a production from murine splenocytes stimulated with LPS with IC50 of 7 nM. [1] EVP4593 (300 nM) entails a significant decrease of amplitude of store-operated currents (approximately by 60%), induced by application of 1 μM thapsigargin in Htt138Q cells, thus prevents abnormal store-operated calcium entry. EVP4593 is able to inhibit the activity of channels containing TRPC1 as one of the subunits, but has no effect on homooligomer channels composed exclusively of TRPC1. [2] QNZ (40 nM) completely abolishes the enhancement of neurite number and length evoked by laminin treatment of the schwann cells. QNZ reduces the neurite length by 61.36% of the schwann cells. QNZ significantly inhibits laminin-induced neurite outgrowth. QNZ also greatly diminishes the neurite elongation after 72 hours culture implying that both initial sprouting and longer term growth and extension seen in response to schwann cells seeded on laminin is mediated by NF-κB. [3] QNZ (10 nM) abolishes LPS-induced up-regulation of CSE expression in rat neutrophil. [4] QNZ (100 nM) blocks the induction effects of GRO/KC on K currents in IB4-negative neurons. [5] |
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In vivo | EVP4593 (1 mg/kg, i.p.) dose-dependently inhibits carrageenin-induced paw edema in rats. [1] |
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, , Cell Death Dis, 2018, 9(6):587
Data from [Data independently produced by , , Oncogene, 2018, 37(7):873-883]
Data from [Data independently produced by , , Cell Physiol Biochem, 2017, 41(1):91-100]
Data from [Data independently produced by , , Nephrol Dial Transplant, 2016: 1–9.]
Tumor-derived apoptotic extracellular vesicle-mediated intercellular communication promotes metastasis and stemness of lung adenocarcinoma [ Bioact Mater, 2024, 36:238-255] | PubMed: 38481566 |
BTLA contributes to acute-on-chronic liver failure infection and mortality through CD4+ T-cell exhaustion [ Nat Commun, 2024, 15(1):1835] | PubMed: 38418488 |
PD-L1-expressing tumor-associated macrophages are immunostimulatory and associate with good clinical outcome in human breast cancer [ Cell Rep Med, 2024, 5(2):101420] | PubMed: 38382468 |
Oncogenic KEAP1 mutations activate TRAF2-NFκB signaling to prevent apoptosis in lung cancer cells [ Redox Biol, 2024, 69:103031] | PubMed: 38184997 |
TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway [ J Adv Res, 2024, S2090-1232(24)00499-5] | PubMed: 39505144 |
Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9 [ iScience, 2024, 27(2):108857] | PubMed: 38303710 |
Ferulic acid suppresses the inflammation and apoptosis in Kawasaki disease through activating the AMPK/mTOR/NF-κB pathway [ Front Pharmacol, 2024, 15:1420602] | PubMed: 39268468 |
Overcoming Irinotecan Resistance by Targeting Its Downstream Signaling Pathways in Colon Cancer [ Cancers (Basel), 2024, 16(20)3491] | PubMed: 39456585 |
A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy [ Adv Sci (Weinh), 2023, 10(15):e2300116] | PubMed: 36950751 |
Hepatic DDAH1 mitigates hepatic steatosis and insulin resistance in obese mice: Involvement of reduced S100A11 expression [ Acta Pharm Sin B, 2023, 13(8):3352-3364] | PubMed: 37655336 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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