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Technical Data
| Formula | C16H20N2O4S2 |
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| Molecular Weight | 368.47 | CAS No. | 1098-97-1 | |
| Solubility (25°C)* | In vitro | DMSO | 60 mg/mL (162.83 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Pyrithioxin (Bonifen, Encefabol, Pyritinol, Vitamin B6 disulfide) is a neurotropic agent which reduces permeability of blood-brain barrier to phosphate. It has no vitamin B6 activity. |
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| In vivo | In old rats, chronic administration of pyritinol increases sensitivity to foot shock and spatial retention. It enhances passive avoidance retention in young and old animals. Acute administration of the drug to young rats reveals a dose-dependent increase in levels of adenosinetriphosphate (ATP) in blood and enhances the age-related decreased utilisation of glucose in various regions of the brain. Chronic treatment with pyritinol elevates the high-affinity uptake of choline in hippocampal and striatal synaptosomes, which is reduced by ageing[1]. |
Protocol (from reference)
| Animal Study: |
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.