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Technical Data
| Formula | C20H24ClN3S.C8H8O8 |
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| Molecular Weight | 606.09 | CAS No. | 84-02-6 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (164.99 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist. | |
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| In vitro | Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2]. | |
| In vivo | Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1]. |
Protocol (from reference)
| Cell Assay:[2] |
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References
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Selleck's Prochlorperazine dimaleate salt has been cited by 4 publications
| Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance [ Cancer Biol Ther, 2023, 24(1):2269637] | PubMed: 37878417 |
| Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance [ Cancer Biol Ther, 2023, 10.1080/15384047.2023.2269637] | PubMed: 37878417 |
| The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis [ Front Microbiol, 2022, 13:979904] | PubMed: 36386620 |
| Open drug discovery for the Zika virus. [ F1000Res, 2016, 5:150] | PubMed: 27134728 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.