Prochlorperazine dimaleate salt

Catalog No.S4631 Batch:S463102

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Technical Data

Formula

C20H24ClN3S.C8H8O8
Molecular Weight 606.09 CAS No. 84-02-6
Solubility (25°C)* In vitro DMSO 74 mg/mL (122.09 mM)
Ethanol 2 mg/mL (3.29 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Prochlorperazine dimaleate salt is a dopamine (D2) receptor antagonist.
Targets
D2 receptor [1]
In vitro Prochlorperazine down-regulates cyclin E2 and reduces cell proliferation in MCF-7 cells that are resistant to tamoxifen. It has the potential to impact on estrogen receptor (ER) function and alter response to endocrine therapy[2].
In vivo Prochlorperazine is showed to be able to induce antinociception in mice. prochlorperazine-treated mice show a complete integrity of motor co-ordination on the rota-rod test, normal spontaneous motility, as well as exploratory behaviour as revealed by the hole-board test. The antinociceptive effect of prochlorperazine appears to be due to the antagonism of D2 receptors since the increase of the pain threshold induced by the investigated compound is prevented by pretreatment with the D2 agonist quinpirole[1].

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    BT474 cells

  • Concentrations

    5 μM

  • Incubation Time

    2 or 5 days

  • Method

    Cells are treated 5 μM of prochlorperazine for 5 days and cell proliferation is measured by methylene blue staining or for 2 days and cyclin E2 mRNA levels are measured by qPCR.

Selleck's Prochlorperazine dimaleate salt has been cited by 4 publications

Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance [ Cancer Biol Ther, 2023, 24(1):2269637] PubMed: 37878417
Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance [ Cancer Biol Ther, 2023, 10.1080/15384047.2023.2269637] PubMed: 37878417
The Food and Drug Administration-approved antipsychotic drug trifluoperazine, a calmodulin antagonist, inhibits viral replication through PERK-eIF2α axis [ Front Microbiol, 2022, 13:979904] PubMed: 36386620
Open drug discovery for the Zika virus. [ F1000Res, 2016, 5:150] PubMed: 27134728

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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