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Technical Data
| Formula | C10H18O |
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| Molecular Weight | 154.25 | CAS No. | 464-43-7 | |
| Solubility (25°C)* | In vitro | DMSO | 30 mg/mL (194.48 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine. |
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| In vitro | (+)-borneol significantly inhibits the expression of iNOS and TNF-α in a dose-dependent manner in the LPS-stimulated BV-2 cells[1]. Aβ-induced cell cytotoxicity is inhibited by 100 μM of (−) and (+) borneol treatment. Treatment of borneol significantly decreases ROS generation. The expression of HO-1 and nuclear translocation of Nrf2 are increased by Aβ treatment. This nuclear translocation of Nrf2 is further increased by administration of borneol. Compared with the Aβ treated group, the (+) borneol treated group significantly increases Bcl-2 expression with decreased expression of Bax. Thus, Borneol protects SH-SY5Y cells against Aβ-induced toxicity, exerts an antioxidative effect and suppresses apoptosis[2]. |
| In vivo | In the rat model of permanent cerebral ischemia, (+)-borneol (1.0 mg/kg) significantly ameliorates infarct size and neurological scoresvia reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) in a dose dependent manner. Notably, (+)-borneol shows long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreases the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. (+)-Borneol obviously loosens the intercellular tight junction in the blood-brain barrier (BBB) and enhances the distribution of drugs in the brain tissue, as it could increase number and volume of pinocytotic vesicles in BBB cells and then promotes the transportation of substance by cell pinocytosis. It contributes to neuroprotection and reduces pro-inflammatory cytokine expression and promotes functional recovery from permanent stroke with a long-term effect in the acute phase of focal permanent cerebral ischemia[1]. |
Protocol (from reference)
| Cell Assay: |
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References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.