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Formula | C14H18Cl2N2O |
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Molecular Weight | 301.21 | CAS No. | 123464-89-1 | |
Solubility (25°C)* | In vitro | DMSO | 46 mg/mL (152.71 mM) | |
Water | 11 mg/mL (36.51 mM) | |||
Ethanol | 4 mg/mL (13.27 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor. | ||||
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Targets |
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In vitro | PNU282987 shows high affinity for the rat α7 nAChR (Ki = 26 nM) and activity at the α7-5-HT3 chimera (EC50 = 128 nM) and showed a negligible block of α1β1γδ and α3β4 nAChRs (≥60 μM). It is inactive at all tested monoamine, muscarine, glutamate, and GABA receptors at 1 μM concentration, except 5-HT3 receptors (Ki = 930 nM). PNU-282987 enhances GABAergic synaptic activity in the hippocampus in vitro[1]. | ||||
In vivo | PNU-282987 reverses amphetamine-induced gating deficit in amphetamine-treated rats[1]. |
Animal Study: |
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