Phytol

Catalog No.S5121 Batch:S512101

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Technical Data

Formula

C20H40O
Molecular Weight 296.53 CAS No. 150-86-7
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
Targets
PPARα [3]
In vitro Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα)[1]. The addition of phytol upregulates the expression of PPARα-target genes at both mRNA and protein levels in PPARα-expressing HepG2 hepatocytes. Phytol is a specific ligand for PPARα, although it can activate PPARγ moderately[3]. In vitro, phytol reduces the motor activity of worms and causes their death. Additionally, phytol at sublethal doses (25 µg/mL) reduces the number of Schistosoma mansoni eggs[4].
In vivo In many animal studies, phytol is used as a precursor of phytanic acid. Addition of phytol to the diet results in an increase of phytol metabolites in tissues and plasma[1]. In vivo, a single dose of phytol (40 mg/kg) administered orally to mice infected with adult S. mansoni results in total and female worm burden reductions of 51.2% and 70.3%, respectively. Moreover, phytol reduces the number of eggs in faeces (76.6%) and the frequency of immature eggs (oogram pattern) is significantly reduced. In medicinal fields, phytol has shown antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. Phytol is an excellent immunostimulant, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity[4].
Density 0.8 g/mL

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Molt 4B cells

  • Concentrations

    10, 20, 40, 80, 100 μM

  • Incubation Time

    3 days

  • Method

    Exponentially growing cells are placed at 3 to 4×l05 cells/ml in the culture flask and cultivated in the presence of vehicle or phytol. After cultivation for 3 days, the cell number is counted by a hemocytometer.
Animal Study:

[4]
  • Animal Models

    Balb/c mice infected with S. mansoni

  • Dosages

    40 mg/kg

  • Administration

    oral

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.