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Technical Data
| Formula | C23H34N3Na2O10P |
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| Molecular Weight | 589.48 | CAS No. | 164204-38-0 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (169.64 mM) | |
| Water | 100 mg/mL (169.64 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively. | |
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| In vitro | Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. [1] Phosphoramidon reduces tumor cell invasion in CC531 cells. [2] | |
| In vivo | In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. [2] Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD). [3] |
Protocol (from reference)
| Animal Study:[2] |
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References
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Selleck's Phosphoramidon Disodium Salt has been cited by 2 publications
| Evaluation of 68Ga-Radiolabeled Peptides for HER2 PET Imaging [ Diagnostics, 2022, 12(11)] | PubMed: None |
| Evaluation of 68Ga-Radiolabeled Peptides for HER2 PET Imaging [ Diagnostics (Basel), 2022, 12(11)2710] | PubMed: 36359554 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.