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Technical Data
| Formula | C9H10N2O |
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| Molecular Weight | 162.19 | CAS No. | 92-43-3 | |
| Solubility (25°C)* | In vitro | DMSO | 32 mg/mL (197.29 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Phenidone (1-phenyl-3-pyrazolidinone), a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound that is primarily used as a photographic developer. | ||
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| Targets |
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| In vivo | Phenidone has provided neuroprotection in various experimental paradigms of neurodegeneration including kainate-induced excitotoxicity, ischemia, microglia-mediated neurotoxicity, and autoimmune encephalomyelitis. However, the neuroprotective effect of the compound appeared to be associated not only with inhibition of COX and LOX activities but also with its direct antioxidant property. Microglia-related neurotoxicity is believed to be partially mediated by oxidative/nitrosative stress[1]. |
Protocol (from reference)
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.