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Technical Data
| Formula | C18H11F3N2O |
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| Molecular Weight | 328.29 | CAS No. | 1462249-75-7 | |
| Solubility (25°C)* | In vitro | DMSO | 15 mg/mL (45.69 mM) | |
| Ethanol | 4 mg/mL (12.18 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors. | |
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| In vitro | PFK158 results in reduced glucose uptake, ATP production, lactate release as well as induction of apoptosis in gynecologic cancer cells. PFK158 treatment sensitizes chemoresistant cells and induces cell death[1]. |
Protocol (from reference)
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Selleck's PFK158 has been cited by 7 publications
| Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance [ Nat Metab, 2022, 4(10):1287-1305] | PubMed: 36203054 |
| Glycolysis Dependency as a Hallmark of SF3B1-Mutated Cells [ Cancers (Basel), 2022, 14(9)2113] | PubMed: 35565242 |
| In Vivo Targeting Replication Protein A for Cancer Therapy [ Front Oncol, 2022, 12:826655] | PubMed: 35251993 |
| Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes [ Front Immunol, 2021, 12:669456] | PubMed: 34163475 |
| Glycolysis Inhibition Induces Functional and Metabolic Exhaustion of CD4+ T Cells in Type 1 Diabetes [ Front Immunol, 2021, 12:669456] | PubMed: 34163475 |
| Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer [ Cancer Metab, 2021, 9(1):33] | PubMed: 34556188 |
| Deamidation Shunts RelA From Mediating Inflammation to Aerobic Glycolysis [ Cell Metab, 2020, 5;31(5):937-955e7] | PubMed: 32325032 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.