Peficitinib

Catalog No.S7650 Batch:S765002

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Technical Data

Formula

C18H22N4O2
Molecular Weight 326.39 CAS No. 944118-01-8
Solubility (25°C)* In vitro DMSO 65 mg/mL (199.14 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.25mg/ml Taking the 1 mL working solution as an example, add 50 μL 65 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Peficitinib is an orally bioavailable JAK inhibitor. Phase 3.
Targets
JAK [1]
In vitro

ASP015K suppresses the IL-2-induced proliferation of human T cells with greater potency than EPO-induced proliferation of human erythroleukemia cells. In human whole blood, ASP015K inhibits STAT5 phosphorylation (pSTAT5). [1]
In vivo

In the rat AIA model, ASP015K (p.o.) significantly decreases paw swelling and ankle bone destruction score. [1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Rat splenocytes

  • Concentrations

    10 nM

  • Incubation Time

    3 days

  • Method

    Splenocytes were then incubated with IL-2 and peficitinib at designated concentrations in 96-well tissue culture plates
Animal Study:

[1]
  • Animal Models

    Female Lewis rats

  • Dosages

    1, 3, 10, and 30 mg/kg

  • Administration

    p.o.

Selleck's Peficitinib has been cited by 3 publications

A panel of janus kinase inhibitors identified with anti-inflammatory effects protect mice from lethal influenza virus infection [ Antimicrob Agents Chemother, 2024, 68(4):e0135023.] PubMed: 38470034
Dasabuvir alleviates 5-fluorouracil-induced intestinal injury through anti-senescence and anti-inflammatory [ Sci Rep, 2024, 14(1):15730] PubMed: 38977864
Peficitinib ameliorates doxorubicin-induced cardiotoxicity by suppressing cellular senescence and enhances its antitumor activity [ Int Immunopharmacol, 2023, 122:110630] PubMed: 37451017

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.