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Technical Data
| Formula | C16H14BrN3O2 |
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| Molecular Weight | 360.21 | CAS No. | 153436-54-5 | |
| Solubility (25°C)* | In vitro | DMSO | 6 mg/mL (16.65 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM). | ||
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| Targets |
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| In vitro | PD153035 inhibits EGF-dependent EGF receptor phosphorylation and suppresses the proliferation and cbonogenicity of a wide panel of EGF receptor-overexpressing human cancer cell lines. EGF receptor autophosphorylation in response to exogenous EGF can be completely inhibited at PD153035 concentrations of >75 nM in cells overexpressing the EGF receptor[1]. |
Protocol (from reference)
References
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Selleck's PD153035 has been cited by 17 publications
| Driving role of head and neck cancer cell secretome on the invasion of stromal fibroblasts: Mechanistic insights by phosphoproteomics [ Biomed Pharmacother, 2023, 158:114176] | PubMed: 36916400 |
| Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer [ Cell Death Discov, 2023, 10.1038/s41420-023-01701-w] | PubMed: 37919290 |
| Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast Reprogramming [ Sci Signal, 2022, 15(728):eabj6915] | PubMed: 35380879 |
| The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways [ Sci Signal, 2022, 15(728):eabj6915] | PubMed: 35380879 |
| Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [ J Biol Chem, 2022, 298(10):102419] | PubMed: 36037968 |
| Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin [ J Biol Chem, 2022, 298(10):102419] | PubMed: 36037968 |
| Control of osteoblast regeneration by a train of Erk activity waves [ Nature, 2021, 10.1038/s41586-020-03085-8] | PubMed: 33408418 |
| Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration [ Int J Mol Sci, 2021, 22(8)3945] | PubMed: 33920448 |
| Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells [ FEBS Lett, 2021, 595(5):563-576] | PubMed: 33421110 |
| Identification of chemical compounds regulating PD-L1 by introducing HiBiT-tagged cells [ FEBS Lett, 2021, 10.1002/1873-3468.14032] | PubMed: 33421110 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.