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Technical Data
| Formula | C11H8FNO2S
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| Molecular Weight | 237.25 | CAS No. | 179461-52-0 | |
| Solubility (25°C)* | In vitro | DMSO | 47 mg/mL (198.1 mM) | |
| Ethanol | 47 mg/mL (198.1 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. | ||||
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| In vitro | In SY5Y cells, PD151746 effectively attenuates the SLLVY-AMC hydrolysis induced by maitotoxin. [1] In HMEC-1 cells, PD 151746 decreases cytotoxicity induced by oxidized low-density lipoprotein (oxLDL). [2] |
Protocol (from reference)
References
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Customer Product Validation
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Data from [Data independently produced by , , PLoS One, 2017, 12(1):e0169788. ]
Selleck's PD 151746 has been cited by 5 publications
| Hepatitis C virus induces oxidation and degradation of apolipoprotein B to enhance lipid accumulation and promote viral production [ PLoS Pathog, 2021, 17(9):e1009889] | PubMed: 34492079 |
| Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke [ Cell, 2019, 177(5):1262-1279] | PubMed: 31056284 |
| Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of Akt/eNOS/NO pathway. [ Life Sci, 2019, 222:195-202] | PubMed: 30807754 |
| Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells. [ Toxicol Lett, 2019, 306:25-34] | PubMed: 30742880 |
| Human S100A7 Induces Mature Interleukin1α Expression by RAGE-p38 MAPK-Calpain1 Pathway in Psoriasis. [ PLoS One, 2017, 12(1):e0169788] | PubMed: 28060905 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.