Pantoprazole

Catalog No.S2105 Batch:S210501

Technical Data

Formula	C₁₆H₁₅F₂N₃O₄S
Molecular Weight	383.37	CAS No.	102625-70-7
Solubility (25°C)*	In vitro	DMSO	76 mg/mL (198.24 mM)
		Ethanol	76 mg/mL (198.24 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description

Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.

Targets

(H+/K+)-ATPase ^[1]

Proton pump ^[1]

In vitro

PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)^[2]. Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole^[3].

In vivo

i.p. injection of pantoprazole in HCT 116 colon tumor-bearing mice effectively suppresses cancer growth. The TOPK downstream signaling molecule phospho-histone H3 in tumor tissues is also decreased after pantoprazole treatment^[3]. At higher infusion rates, pantoprazole is able to induce negative hemodynamic responses, in particular, in the setting of heart failure. These effects can lead to significant impairment of cardiac function^[4]. Also, pantoprazole delays fracture healing by affecting both bone formation and bone remodeling^[5].

Protocol (from reference)

Cell Assay:^{^[2]}	Cell lines SGC-7901 cells Concentrations 5 mg/ml Incubation Time 24 h Method The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1x10⁴/well, in 96-well plates and treated with 5 mg/ml PPZ for 24 h. The cytotoxicity of PPZ is assessed by a cell counting kit-8 assay. The cytotoxicity is expressed as the relative cell viability, using the following formula: Cell viability (%) = (OD of drug-treated sample/OD of untreated sample) x 100. The experiment is repeated 3 times.
Animal Study:^{^[3]}	Animal Models Non-obese Diabetic/Severe Combined Immunodeficiency (NOD-SCID) mice Dosages 100 mg/kg Administration i.p.

Cell Assay:^{^[2]}

Cell lines
SGC-7901 cells
Concentrations
5 mg/ml
Incubation Time
24 h
Method
The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1x10⁴/well, in 96-well plates and treated with 5 mg/ml PPZ for 24 h. The cytotoxicity of PPZ is assessed by a cell counting kit-8 assay. The cytotoxicity is expressed as the relative cell viability, using the following formula: Cell viability (%) = (OD of drug-treated sample/OD of untreated sample) x 100. The experiment is repeated 3 times.

Animal Study:^{^[3]}

Animal Models
Non-obese Diabetic/Severe Combined Immunodeficiency (NOD-SCID) mice
Dosages
100 mg/kg
Administration
i.p.

References

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Selleck's Pantoprazole has been cited by 5 publications

A drug repurposing study identifies novel FOXM1 inhibitors with in vitro activity against breast cancer cells [ Med Oncol, 2024, 41(8):188]	PubMed: 38918225
Hyperglycemia in Pregnancy-Associated Oxidative Stress Augments Altered Placental Glucose Transporter 1 Trafficking via AMPKα/p38MAPK Signaling Cascade [ Int J Mol Sci, 2022, 23-158572]	PubMed: 35955706
Evaluation of an Ussing Chamber System Equipped with Rat Intestinal Tissues to Predict Intestinal Absorption and Metabolism in Humans [ Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x]	PubMed: 35733077
Ilaprazole and other novel prazole-based compounds that bind Tsg101 inhibit viral budding of HSV-1/2 and HIV from cells [ J Virol, 2021, JVI.00190-21]	PubMed: 33731460
Omeprazole Increases the Efficacy of Acyclovir Against Herpes Simplex Virus Type 1 and 2. [ Front Microbiol, 2019, 10:2790]	PubMed: 31849920

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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