Palbociclib

Catalog No.S4482 Batch:S448201

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Technical Data

Formula

C24H29N7O2
Molecular Weight 447.53 CAS No. 571190-30-2
Solubility (25°C)* In vitro 5% TFA 5 mg/mL (11.17 mM)
DMSO Insoluble
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Palbociclib (PD 0332991) is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4) and Cdk6 with IC50 of 11 nM and 16 nM, respectively.This product has poor solubility, animal experiments are available, cell experiments please choose carefully!
Targets
Cdk4 [1]
(Cell-free assay)		 Cdk6 [1]
(Cell-free assay)
11 nM 16 nM

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    BT474 and MDA-MB-361 tumor cell lines

  • Concentrations

    0-15 μM

  • Incubation Time

    72 h

  • Method

    Cell viability is measured by Cell Titer Glo assay after 72 hours of treatment with vehicle or drugs. For all experiments with fulvestrant, cells are grown in estrogen free conditions, and estradiol is added to a final concentration of 10-8 M prior to drug treatment.

Selleck's Palbociclib has been cited by 149 publications

Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment [ Cancer Cell, 2024, S1535-6108(24)00037-0] PubMed: 38402610
Proteogenomic insights into the biology and treatment of pan-melanoma [ Cell Discov, 2024, 10(1):78] PubMed: 39039072
Transcription-coupled DNA-protein crosslink repair by CSB and CRL4CSA-mediated degradation [ Nat Cell Biol, 2024, 10.1038/s41556-024-01394-y] PubMed: 38600236
HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes [ Nat Commun, 2024, 15(1):4450] PubMed: 38789411
A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis [ Nat Commun, 2024, 15(1):775] PubMed: 38278798
Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure [ Nat Commun, 2024, 15(1):3490] PubMed: 38664429
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors [ Nat Commun, 2024, 15(1):7460] PubMed: 39198430
The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence [ Nucleic Acids Res, 2024, gkae426] PubMed: 38783095
Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma [ Clin Cancer Res, 2024, 30(4):703-718] PubMed: 37695642
Combined inhibition of CDK4/6 and AKT is highly effective against the luminal androgen receptor (LAR) subtype of triple negative breast cancer [ Cancer Lett, 2024, 604:217219] PubMed: 39244005

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Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.