Oxibendazole

Catalog No.S1851 Batch:S185102

Technical Data

Formula

C₁₂H₁₅N₃O₃

Molecular Weight

249.27

CAS No.

20559-55-1

Solubility (25°C)*

In vitro

DMSO

3 mg/mL (12.03 mM)

Water

Insoluble

Ethanol

Insoluble

In vivo (Add solvents to the product individually and in order)

Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	0.15mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	0.15mg/ml	Taking the 1 mL working solution as an example, add 50 μL of 3 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.
In vivo	Oxibendazole shows a significant reduction of the proportion of positive foals after treatment. Oxibendazole significantly reduces the proportion of positive horse foals on six of the seven farms (86%). ^[1] Oxibendazole reduces in the number of strongyle eggs/g (epg) in horse, but the reduction is only by 82% with an upper confidence limit of 89%. ^[2] Oxibendazole results in collapse of the lip papillae, rupture of buccal cavity cuticle, prolapse of the pharynx, degeneration of epithelial cells and erosion of microvilli in adult Ascaris suum, theses changes may lead to impaired digestion and absorption of nutrients and cause cellular autolysis, resulting in the death of the worm. ^[3] Oxibendazole reduces faecal worm egg counts (EPG) by 97.6% for Toxocara canis, 95.7% for Trichuris vulpis, 94.6% for Ancylostoma caninum, and 100% for Toxascaris leonine in dogs and cats. ^[4] Oxibendazole could only be detected in plasma at the 0.5 hours and 1.0 hours post administration sampling times and the mean maximum plasma concentration is 0.008 mg/mL in horse. Oxibendazole is detected in faeces between 12 and 72 hours after administration and the highest dry faecal concentration was detected at 24 hours. ^[5]

Description

Oxibendazole is a benzimidazole drug that interferes with metabolic pathways, used to protect against roundworms, strongyles, threadworms, pinworms and lungworm infestations in horses and some domestic pets.

In vivo

Oxibendazole shows a significant reduction of the proportion of positive foals after treatment. Oxibendazole significantly reduces the proportion of positive horse foals on six of the seven farms (86%). ^[1] Oxibendazole reduces in the number of strongyle eggs/g (epg) in horse, but the reduction is only by 82% with an upper confidence limit of 89%. ^[2] Oxibendazole results in collapse of the lip papillae, rupture of buccal cavity cuticle, prolapse of the pharynx, degeneration of epithelial cells and erosion of microvilli in adult Ascaris suum, theses changes may lead to impaired digestion and absorption of nutrients and cause cellular autolysis, resulting in the death of the worm. ^[3] Oxibendazole reduces faecal worm egg counts (EPG) by 97.6% for Toxocara canis, 95.7% for Trichuris vulpis, 94.6% for Ancylostoma caninum, and 100% for Toxascaris leonine in dogs and cats. ^[4] Oxibendazole could only be detected in plasma at the 0.5 hours and 1.0 hours post administration sampling times and the mean maximum plasma concentration is 0.008 mg/mL in horse. Oxibendazole is detected in faeces between 12 and 72 hours after administration and the highest dry faecal concentration was detected at 24 hours. ^[5]

Protocol (from reference)

References

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Selleck's Oxibendazole has been cited by 1 publication

Oxibendazole inhibits prostate cancer cell growth. [ Oncol Lett, 2018, 15(2):2218-2226]	PubMed: 29434928

Oxibendazole inhibits prostate cancer cell growth. [ Oncol Lett, 2018, 15(2):2218-2226]

PubMed: 29434928

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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