OTX008

Catalog No.S6949 Batch:S694902

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Technical Data

Formula

C52H72N8O8
Molecular Weight 937.18 CAS No. 286936-40-1
Solubility (25°C)* In vitro Ethanol 25 mg/mL (26.67 mM)
DMSO 5 mg/mL (5.33 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description OTX008 (Calixarene 0118, PTX008), a calixarene derivative, is a selective inhibitor of galectin-1 (Gal1) with anti-tumoural activity.
Targets
galectin-1 [1]
In vitro

OTX008 is a selective inhibitor of galectin-1 (Gal1) with anti-tumoural activity. It affected endothelial cell proliferation, motility, invasiveness, and cord formation.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    A2780-1A9 cells

  • Concentrations

    2.1 μM

  • Incubation Time

    24 h

  • Method

    Cells were treated with various concentrations of drug for 24 h.
Animal Study:

[2]
  • Animal Models

    Female athymic Foxn1 nu/nu mice

  • Dosages

    5 mg/kg

  • Administration

    i.v.

Selleck's OTX008 has been cited by 3 publications

Chrysin Directing an Enhanced Solubility through the Formation of a Supramolecular Cyclodextrin-Calixarene Drug Delivery System: A Potential Strategy in Antifibrotic Diabetes Therapeutics [ Pharmaceuticals (Basel), 2024, 17(1)107] PubMed: 38256940
Chrysin-based supramolecular cyclodextrin-calixarene drug delivery system: a novel approach for attenuating cardiac fibrosis in chronic diabetes [ Front Pharmacol, 2023, 14:1332212] PubMed: 38169923
Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway [ Molecules, 2022, 27(15)4785] PubMed: 35897964

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.