Otilonium Bromide

Catalog No.S3047 Batch:S304701

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Technical Data

Formula

C29H43BrN2O4

Molecular Weight 563.57 CAS No. 26095-59-0
Solubility (25°C)* In vitro DMSO 113 mg/mL (200.5 mM)
Water 113 mg/mL (200.5 mM)
Ethanol 113 mg/mL (200.5 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Otilonium bromide is an antimuscarinic.
Targets
mAChR [1]
In vitro Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. [1] This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect. [2]

Protocol (from reference)

Selleck's Otilonium Bromide has been cited by 2 publications

Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines [ Biochem Pharmacol, 2023, 215:115746] PubMed: 37579857
Therapeutic potential of otilonium bromide against Vibrio vulnificus [ Res Microbiol, 2022, S0923-2508(22)00073-0] PubMed: 36122890

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.