Orcinol glucoside

Catalog No.S3828 Batch:S382801

Technical Data

Formula	C₁₃H₁₈O₇
Molecular Weight	286.28	CAS No.	21082-33-7
Solubility (25°C)*	In vitro	DMSO	57 mg/mL (199.1 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects.
In vivo	Orcinol glucoside (OG) has an antidepressant effect in rats. OG (5, 10, and 20 mg/kg) increases the time spent in open arms and the number of entries into open arms in the elevated plus-maze test. OG (5 and 10 mg/kg) increases the number of head-dips in the hole-board test. At all tested doses, OG does not significantly affect the locomotion of mice in the open-field test. OG is anxiolytic agents without sedative effects^[1].

Description

Orcinol glucoside (OG, Sakakin) is an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn. It shows potent antioxidative and anxiolytic activities without sedative effects.

In vivo

Orcinol glucoside (OG) has an antidepressant effect in rats. OG (5, 10, and 20 mg/kg) increases the time spent in open arms and the number of entries into open arms in the elevated plus-maze test. OG (5 and 10 mg/kg) increases the number of head-dips in the hole-board test. At all tested doses, OG does not significantly affect the locomotion of mice in the open-field test. OG is anxiolytic agents without sedative effects^[1].

Protocol (from reference)

Animal Study:^{^[1]}	Animal Models Male CD-1 mice Dosages 5, 10, or 20 mg/kg Administration oral administration

References

[1] Wang X, et al. Pharm Biol. 2015, 53(6):876-81.

Selleck's Orcinol glucoside has been cited by 1 publication

Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway. [ Drug Des Devel Ther, 2019, 13:2703-2713]	PubMed: 31496649

Orcinol glucoside facilitates the shift of MSC fate to osteoblast and prevents adipogenesis via Wnt/β-catenin signaling pathway. [ Drug Des Devel Ther, 2019, 13:2703-2713]

PubMed: 31496649

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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