ONO-AE3-208

Catalog No.E2986 Batch:E298601

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Technical Data

Formula

C24H21FN2O3
Molecular Weight 404.43 CAS No. 402473-54-5
Solubility (25°C)* In vitro DMSO 81 mg/mL (200.28 mM)
Ethanol 3 mg/mL (7.41 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
5% DMSO 95% Corn oil
0.65mg/ml
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
4.05mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ONO-AE3-208(AE 3-208) is a selective and orally active EP4 receptor antagonist with a Ki of 1.3 nM, less potent to EP3, FP, and TP receptors with Ki of 30 nM, 790 nM, and 2400 nM, respectively.
Targets
EP4 [1] EP3 [1] FP [1] TP [1]
1.3 nM(Ki) 30 nM(Ki) 790 nM(Ki) 2400 nM(Ki)

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.