Olodaterol

Catalog No.S4485 Batch:S448501

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Technical Data

Formula

C21H26N2O5
Molecular Weight 386.44 CAS No. 868049-49-4
Solubility (25°C)* In vitro DMSO 77 mg/mL (199.25 mM)
Ethanol 40 mg/mL (103.5 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Olodaterol is a long-acting β2-adrenergic receptor agonist that is used as a component of an inhalation (Tiotropium/Olodaterol) for treating patients with chronic obstructive pulmonary disease (COPD).
Targets
β2-adrenergic receptor [1]
In vivo

The bronchoprotective half-life of abediterol in guinea pigs is 47 h for olodaterol. In anaesthetised dogs, olodaterol inhibits acetylcholine-induced bronchoconstriction, with ID40 (dose inhibiting bronchoconstriction by 40%) of 0.180 µg/kg. In parallel, effect on heart rate in dogs is measured, showing a safety index (defined as the ratio of the maximal dose without effect on heart rate and the ID40) of 10.5.[2]

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    guinea pigs (bodyweight 340–580 g); male Beagle dogs

  • Dosages

    0.03, 0.1, 0.3, 3, 10 and 30 mg/ml for guinea pigs; 0.1, 1, and 10 mg/kg for dogs

  • Administration

    aerosolised; respiratory pump

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.