ODM-203

Catalog No.S8882 Batch:S888201

Print

Technical Data

Formula

C26H21F2N5O2S
Molecular Weight 505.54 CAS No. 1430723-35-5
Solubility (25°C)* In vitro DMSO 100 mg/mL (197.8 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively.
Targets
VEGFR3 [1]
(Cell-free assay)		 FGFR3 [1]
(Cell-free assay)		 VEGFR2 [1]
(Cell-free assay)		 FGFR1 [1]
(Cell-free assay)		 FGFR2 [1]
(Cell-free assay)		 View More
5 nM 6 nM 9 nM 11 nM 16 nM
In vitro

In cellular assays, ODM-203 inhibits VEGFR-induced tube formation (IC50 33 nmol/L) with similar potency as it inhibits proliferation in FGFR-dependent cell lines such as H1581,SNU16,and RT4 cells (IC50 50-150 nmol/L). [1]
In vivo

In vivo, ODM-203 shows strong antitumor activity in both FGFR-dependent xenograft models and in an angiogenic xenograft model at similar well-tolerated doses.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    H1581,SNU16,and RT4 cells

  • Concentrations

    up to 3 μmol/L

  • Incubation Time

    96 h

  • Method

    The cells were allowed to attach overnight and then subsequently treated with the test compounds with an eight-dose concentration series up to 3 μmol/L for 96 hours.
Animal Study:

[1]
  • Animal Models

    Subcutaneous Renca syngenic model

  • Dosages

    20 and 40 mg/kg

  • Administration

    Oral gavage

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.