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Technical Data
| Formula | C38H40N10 |
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| Molecular Weight | 636.79 | CAS No. | 81624-55-7 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (157.03 mM) | |
| Ethanol | 100 mg/mL (157.03 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM. | ||||
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| In vitro | NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. It disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53 and induces apoptosis[1]. | ||||
| In vivo | In vivo invasion and intravasation (that is, the number of CTCs) are significantly inhibited after injection of NSC348884(as an inhibitor of NPM1 oligomerization) into the tumor-bearing mice. No significant difference in overall cell death is observed by histology in the treated tumors with the 4-hour brief treatments, suggesting that the inhibition seen is specific to migration.[2]. |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's NSC348884 has been cited by 5 publications
| The EGFR/ErbB inhibitor neratinib modifies the neutrophil phosphoproteome and promotes apoptosis and clearance by airway macrophages [ Front Immunol, 2022, 13:956991] | PubMed: 35967296 |
| NPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer. [ Nat Commun, 2020, 3;11(1):1669] | PubMed: 32245950 |
| Nucleolar protein NPM1 is essential for circovirus replication by binding to viral capsid [ Virulence, 2020, 11(1):1379-1393] | PubMed: 33073687 |
| Nucleolar stress regulates stromal-epithelial transition via NPM1 during decidualization [ Reproduction, 2020, 160(4):491-500] | PubMed: 32817586 |
| Nucleolar stress regulation of endometrial receptivity in mouse models and human cell lines. [ Cell Death Dis, 2019, 10(11):831] | PubMed: 31685803 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.