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Technical Data
| Formula | C11H9N3S |
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| Molecular Weight | 215.27 | CAS No. | 39122-38-8 | |
| Solubility (25°C)* | In vitro | DMSO | 43 mg/mL (199.74 mM) | |
| Ethanol | 21 mg/mL (97.55 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways. | |
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Protocol (from reference)
Selleck's NSC 185058 has been cited by 3 publications
| Protocol for quantifying LC3B FRET biosensor activity in living cells using a broad-to-sensitive data analysis pipeline [ STAR Protoc, 2024, 5(3):103181] | PubMed: 39178110 |
| Inhibition of the ATG4-LC3 pathway suppressed osteoclast maturation [ Biochem Biophys Res Commun, 2022, 632:40-47] | PubMed: 36198202 |
| Deacetylation of ATG4B promotes autophagy initiation under starvation [ Sci Adv, 2022, 8(31):eabo0412] | PubMed: 35921421 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.