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Technical Data
| Formula | C28H25ClF3N7O2 |
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| Molecular Weight | 583.99 | CAS No. | 923288-90-8 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (171.23 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Nilotinib (AMN-107, Tasigna) hydrochloride monohydrate is a selective and orally bioavailable inhibitor of Bcr-Abl with IC50 < 30 nM in Murine myeloid progenitor cells. Nilotinib induces autophagy through AMPK activition. | ||||
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Protocol (from reference)
Selleck's Nilotinib hydrochloride monohydrate has been cited by 12 publications
| Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation [ Nat Commun, 2024, 15(1):2089] | PubMed: 38453961 |
| Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells [ J Pharm Sci, 2022, 111(8):2180-2190] | PubMed: 35700798 |
| Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix-mediated tumor cell adaptation and tolerance to BRAF-targeted therapy in melanoma [ EMBO Mol Med, 2021, e11814] | PubMed: 34957688 |
| Antimetabolic cooperativity with the clinically approved l-asparaginase and tyrosine kinase inhibitors to eradicate CML stem cells [ Mol Metab, 2021, 55:101410] | PubMed: 34863941 |
| CXCR2, a novel target to overcome tyrosine kinase inhibitor resistance in chronic myelogenous leukemia cells [ Biochem Pharmacol, 2021, 190:114658] | PubMed: 34146540 |
| Imatinib can act as an Allosteric Activator of Abl Kinase [ J Mol Biol, 2021, 434(2):167349] | PubMed: 34774565 |
| Statins Enhance the Molecular Response in Chronic Myeloid Leukemia when Combined with Tyrosine Kinase Inhibitors [ Cancers (Basel), 2021, 13(21)5543] | PubMed: 34771705 |
| ABL1 and Cofilin1 promote T-cell acute lymphoblastic leukemia cell migration [ Acta Biochim Biophys Sin (Shanghai), 2021, gmab117] | PubMed: 34508625 |
| Crizotinib acts as ABL1 inhibitor combining ATP-binding with allosteric inhibition and is active against native BCR-ABL1 and its resistance and compound mutants BCR-ABL1T315I and BCR-ABL1T315I-E255K [ Ann Hematol, 2021, 10.1007/s00277-020-04357-z] | PubMed: 34110462 |
| Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia [ Leuk Lymphoma, 2017, 58(8):1903-1913] | PubMed: 27931141 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.