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Technical Data
| Formula | C11H15ClN2O5 |
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| Molecular Weight | 290.7 | CAS No. | 23111-00-4 | |
| Solubility (25°C)* | In vitro | DMSO | 58 mg/mL (199.51 mM) | |
| Water | 58 mg/mL (199.51 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements. |
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| In vitro | Nicotinamide Riboside supplementation increases NAD+ content and sirtuin activity in cultured mammalian cells.[1] |
| In vivo | Nicotinamide Riboside, a precursor to nicotinamide adenine dinucleotide(NAD), restores tissue NAD+ depletion induced by acute kidney injury (AKI) to that of the sham group, increases autophagy and sirtuin1 (Sirt1).[2] |
Protocol (from reference)
| Cell Assay: |
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| Animal Study: |
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References
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Selleck's Nicotinamide Riboside Chloride has been cited by 6 publications
| Complex I deficiency in m.3243A>G fibroblasts is alleviated by reducing NADH accumulation [ Front Physiol, 2023, 14:1164287] | PubMed: 37650111 |
| DEVELOPMENT OF MURINE BRAIN ORGANOIDS AND THEIR APPLICATON FOR DISEASE MODELING [ IRIS, 2023, ] | PubMed: none |
| Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming [ Cell Discov, 2022, 8(1):106] | PubMed: 36220812 |
| Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation [ Cell Death Differ, 2022, 10.1038/s41418-022-00992-3] | PubMed: 35568718 |
| Aberrant NAD+ metabolism underlies Zika virus-induced microcephaly [ Nat Metab, 2021, 3(8):1109-1124] | PubMed: 34385701 |
| Effect of NAD+ boosting on kidney ischemia-reperfusion injury [ PLoS One, 2021, 16(6):e0252554] | PubMed: 34061900 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.