Neticonazole

Catalog No.S5080 Batch:S508001

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Technical Data

Formula

C17H22N2OS
Molecular Weight 302.43 CAS No. 130726-68-0
Solubility (25°C)* In vitro DMSO 60 mg/mL (198.39 mM)
Water 60 mg/mL (198.39 mM)
Ethanol 60 mg/mL (198.39 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Neticonazole (SS717) is a selecvie inhibitor of exosome biogenesis and secretion. Neticonazole exhibits Neticonazole antifungal and antitumor activity.
Targets
exosome [1]
In vivo

Neticonazole treatment significantly reduces the Bcl-2/Bax ratio, leading to the restoration of the apoptosis level in xenograft tumors, which echoes the observation of inhibited tumor growth in neticonazole-treated IDB mice.[4]

Protocol (from reference)

Animal Study:

[4]
  • Animal Models

    Male C57BL/6 mice of intestinal dysbacteriosis (IDB) model bearing CRC xenograft tumors

  • Dosages

    100, 10 and 1 ng/kg body weight

  • Administration

    o.g.

Selleck's Neticonazole has been cited by 3 publications

Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer [ Nat Commun, 2023, 14(1):6692] PubMed: 37872156
Dual targeted extracellular vesicles regulate oncogenic genes in advanced pancreatic cancer [ Nat Commun, 2023, 14(1):6692] PubMed: 37872156
Extracellular vesicle expansion of PMIS-miR-210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism [ Clin Transl Med, 2022, 12(9):e1037] PubMed: 36116139

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.