Narciclasine

Catalog No.E1124 Batch:E112401

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Technical Data

Formula

C14H13NO7
Molecular Weight 307.26 CAS No. 29477-83-6
Solubility (25°C)* In vitro DMSO 61 mg/mL (198.52 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Narciclasine (Lycoricidinol), an isocarbostyril alkaloid narciclasine, targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Narciclasine suppresses phosphorylation, activation, dimerization, and nuclear translocation of STAT3 by directly binding with the STAT3 SH2 domain and leads STAT3 degradation. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.
Targets
STAT3 [1]
In vitro

Narciclasine activates Rho and stress fibers in glioblastoma multiforme cells. The mean IC50 of ~50 nM calculated on the 6 human glioblastoma multiforme (U373, Hs683, GL19, GL5, GL16, GL17), The mean IC50 value of 47 nM for Narciclasine across a panel of 60 cancer cell lines. [2]
In vivo

Narciclasine significantly increases the survival of GL19 glioblastoma multiforme-bearing mice, and the survival of Hs683 glioblastoma multiforme-bearing mice. [2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Human glioblastoma multiforme cell lines

  • Concentrations

    0.001-10 μM

  • Incubation Time

    72 h

  • Method

    The cells are incubated for 72 h in the presence and absence of the narciclasine (0.001-10 μM) for the determination of narciclasine IC50 values by colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay.
Animal Study:

[2]
  • Animal Models

    GL19 glioblastoma multiforme-bearing mice

  • Dosages

    1 mg/kg

  • Administration

    i.v., p.o.

Selleck's Narciclasine has been cited by 2 publications

Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling [ Acta Biomater, 2024, S1742-7061(24)00036-9] PubMed: 38272199
The mechanics of local niches in the primary tumor regulate breast cancer brain metastasis [ POLYU ELECTRONIC THESES, 2023, viii, 164] PubMed: None

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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