Namodenoson (CF-102)

Catalog No.S0498 Batch:S049802

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Technical Data

Formula

C18H18ClIN6O4
Molecular Weight 544.73 CAS No. 163042-96-4
Solubility (25°C)* In vitro DMSO 100 mg/mL (183.57 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR) with Ki of 0.33 nM. Namodenoson exerts an anti‑NASH effect mediated via the de‑regulation of the PI3K/NF‑κB/Wnt/β‑catenin signaling pathway.
Targets
A3AR [1]
(Cell-free assay)
0.33 nM(Ki)
In vitro

Namodenoson (CF-102, 2-Cl-IB-MECA) is an orally bioavailable and selective agonist of the A3 adenosine receptor (A3AR).

Protocol (from reference)

Cell Assay:

[3]
  • Cell lines

    LX2 cells

  • Concentrations

    10 nM

  • Incubation Time

    48 h

  • Method

    Cells were treated with indicated concentrations of drug for 48 h.
Animal Study:

[3]
  • Animal Models

    Male C57bl/6J mice

  • Dosages

    100 µg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.