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Formula | C5H10N2O2S |
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Molecular Weight | 162.21 | CAS No. | 38520-57-9 | |
Solubility (25°C)* | In vitro | DMSO | 32 mg/mL (197.27 mM) | |
Water | 32 mg/mL (197.27 mM) | |||
Ethanol | 11 mg/mL (67.81 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. | |||
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Targets |
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In vitro | The antioxidant N-acetylcysteine (NAC) blocks erastin-induced or RSL3-induced cell death in Nupr1-/- mPDAC cells, an effect that is associated with decreased production or release of MDA, 8-OHdG, or HMGB1. NUPR1-knockdown PANC1 cells exhibits increased MDA, 8-OHdG, and HMGB1 release during ferroptotic cell death, which can be reversed by the addition of NAC.[2] |
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In vivo | Combined n-acetylcysteine (NAC) and bone marrow-derived mesenchymal stem cells (BMSCs) therapy alleviates oxidative stress damage to the pancreas and inhibits the inflammatory response to a significantly greater extent than single therapy with either BMSCs or NAC.[3] |
Cell Assay: |
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Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis [ Redox Biol, 2024, 72:103137] | PubMed: 38642502 |
Base-excision repair pathway regulates transcription-replication conflicts in pancreatic ductal adenocarcinoma [ Cell Rep, 2024, 43(10):114820] | PubMed: 39368091 |
ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells [ Oncol Rep, 2024, 52(3)122] | PubMed: 39054955 |
Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [ Nat Commun, 2023, 14(1):5165] | PubMed: 37620297 |
Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons [ Nat Commun, 2023, 14(1):5165] | PubMed: 37620297 |
Omicron Spike Protein is Vulnerable to Reduction [ J Mol Biol, 2023, 435(13):168128] | PubMed: 37100168 |
Omicron Spike Protein is Vulnerable to Reduction [ J Mol Biol, 2023, 435(13):168128] | PubMed: 37100168 |
Comprehensive analysis of cuproptosis-related lncRNAs for prognostic significance and immune microenvironment characterization in hepatocellular carcinoma [ Front Immunol, 2022, 13:991604] | PubMed: 36685508 |
NUPR1 is a critical repressor of ferroptosis [ Nat Commun, 2021, 12(1):647] | PubMed: 33510144 |
Angiotensin II inhibits osteogenic differentiation of isolated synoviocytes by increasing DKK-1 expression. [ Int J Biochem Cell Biol, 2020, 121:105703] | PubMed: 32014499 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.