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Technical Data
| Formula | C25H16Cl2F6N2O2 |
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| Molecular Weight | 561.30 | CAS No. | 2289691-01-4 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (178.15 mM) | |
| Ethanol | 100 mg/mL (178.15 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities. | |
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| Targets |
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| In vitro | MYCi975 localizes to the same region of the MYC protei. Treatment of cells with MYCi975 enhances MYC degradation and phosphorylation on T58. MYCi975 also directly increases GSK3b-mediated MYC pT58 in the in vitro kinase assay.[1] |
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| In vivo | MYCi975 suppresses in vivo tumor growth in mice, increases tumor immune cell infiltration, upregulates PD-L1 on tumors, and sensitizes tumors to anti-PD1 immunotherapy with good tolerability.[1] |
Biological Activity
| Description | MYCi975 (NUCC-0200975) is a potent, selective and orally active inhibitor of MYC that disrupts MYC/MAX interaction, promotes MYC T58 phosphorylation and MYC degradation, and impairs MYC driven gene expression. MYCi975 exhibits potent anti-tumor activities. | |
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| Targets |
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Protocol (from reference)
Selleck's MYCi975 has been cited by 6 publications
| A program of successive gene expression in mouse one-cell embryos [ Cell Rep, 2023, 42(2):112023] | PubMed: 36729835 |
| Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics [ Cancer Res, 2022, 82(7):1174-1192] | PubMed: 35180770 |
| Loss of G0/G1 switch gene 2 (G0S2) promotes disease progression and drug resistance in chronic myeloid leukaemia (CML) by disrupting glycerophospholipid metabolism [ Clin Transl Med, 2022, 12(12):e1146] | PubMed: 36536477 |
| MEK/ERK-mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function [ Cancer Sci, 2022, 113(4):1264-1276] | PubMed: 35108425 |
| Yap-Myc signaling induces pancreatic stellate cell activation through regulating glutaminolysis [ Exp Cell Res, 2022, 411(1):113000] | PubMed: 34958764 |
| Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics [ bioRxiv, 2021, 10.1101/2021.08.09.455691] | PubMed: None |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.