Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Formula | C15H15NO4S |
||||||||||
Molecular Weight | 305.35 | CAS No. | 173436-66-3 | ||||||||
Solubility (25°C)* | In vitro | DMSO | 61 mg/mL (199.77 mM) | ||||||||
Ethanol | 10 mg/mL (32.74 mM) | ||||||||||
Water | Insoluble | ||||||||||
In vivo (Add solvents to the product individually and in order) |
|
||||||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | MSAB is a selective inhibitor of Wnt/β-catenin signaling that binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects. | |
---|---|---|
Targets |
|
|
In vitro | MSAB impedes RAW264.7 cells and human PMBCs differentiating into OCs. MSAB decreases the expression of β‐catenin in RAW264.7 and ARP1 WT cells.[2] |
|
In vivo | MSAB (10-20 mg/kg; i.p. daily for 2 weeks) inhibits tumor growth of Wnt-dependent cancer cells in xenograft mice and MMTV-Wnt1 transgenic mice.[3] |
Cell Assay: |
|
---|
|
Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis [ Oncogene, 2024, 10.1038/s41388-024-03008-1] | PubMed: 38519641 |
Hyperoxia exposure upregulates Dvl-1 and activates Wnt/β-catenin signaling pathway in newborn rat lung [ BMC Mol Cell Biol, 2023, 24(1):4] | PubMed: 36726071 |
Inhibition of beta-catenin shows therapeutic potential in head and neck squamous cell carcinoma in vitro [ Eur Arch Otorhinolaryngol, 2023, 280(1):399-408] | PubMed: 36001136 |
Inhibition of beta-catenin shows therapeutic potential in head and neck squamous cell carcinoma in vitro [ Eur Arch Otorhinolaryngol, 2023, 280(1):399-408] | PubMed: 36001136 |
Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication [ Clin Transl Med, 2022, 12(2):e684] | PubMed: 35184390 |
Empagliflozin activates Wnt/β-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome [ Mol Metab, 2022, 64:101553] | PubMed: 35863636 |
G-protein-coupled receptor 124 promotes osteogenic differentiation of BMSCs through the Wnt/β-catenin pathway [ In Vitro Cell Dev Biol Anim, 2022, 10.1007/s11626-022-00684-9] | PubMed: 35916978 |
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes [ Front Cell Dev Biol, 2021, 9:648201] | PubMed: 33748142 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.