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Technical Data
| Formula | C22H23N5O |
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| Molecular Weight | 373.45 | CAS No. | 453562-69-1 | |
| Solubility (25°C)* | In vitro | DMSO | 18.2 mg/mL (48.73 mM) | |
| Ethanol | 8 mg/mL (21.42 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively. | |||||||||||
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Protocol (from reference)
Selleck's Motesanib (AMG-706) has been cited by 11 publications
| MrgprF acts as a tumor suppressor in cutaneous melanoma by restraining PI3K/Akt signaling [ Signal Transduct Target Ther, 2022, 7(1):147] | PubMed: 35504869 |
| Anosmin-1-Like Effect of UMODL1/Olfactorin on the Chemomigration of Mouse GnRH Neurons and Zebrafish Olfactory Axons Development [ Front Cell Dev Biol, 2022, 10:836179] | PubMed: 35223856 |
| Preclinical Evaluation of Ixabepilone in Combination with VEGF Receptor and PARP Inhibitors in Taxane-Sensitive and Taxane-Resistant MDA-MB-231 Breast Cancer Cells [ J Pharm Sci, 2022, 111(8):2180-2190] | PubMed: 35700798 |
| Organoid cultures derived from patients with papillary thyroid cancer [ J Clin Endocrinol Metab, 2021, dgab020] | PubMed: 33524147 |
| Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat [ Drug Metab Dispos, 2021, 49(1):53-61] | PubMed: 33148688 |
| Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets [ Cell Chem Biol, 2019, 10.1016/j.chembiol.2019.06.003] | PubMed: 31257184 |
| Multikinase inhibitor motesanib enhances the antitumor effect of cisplatin in cisplatin‑resistant human bladder cancer cells via apoptosis and the PI3K/Akt pathway. [ Oncol Rep, 2019, 41(4):2482-2490] | PubMed: 30816494 |
| [ Cancer Res, 2016, ] | PubMed: 27488524 |
| Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6 [ Int J Oncol, 2015, 47(1):122-32] | PubMed: 25955731 |
| Antiangiogenic effects of topically administered multiple kinase inhibitor, motesanib (AMG 706), on experimental choroidal neovascularization in mice. [ J Ocul Pharmacol Ther, 2015, 31(1):25-31] | PubMed: 25255037 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.