ML385

Catalog No.S8790 Batch:S879001

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Technical Data

Formula

C29H25N3O4S
Molecular Weight 511.59 CAS No. 846557-71-9
Solubility (25°C)* In vitro DMSO 20 mg/mL (39.09 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. NRF2 regulates the activity of several ferroptosis and lipid peroxidation-related proteins.
Targets
Ferroptosis [3] Nrf2 [1]
1.9 μM
In vitro

ML385 shows anti-tumor activity in NSCLC (subcutaneous and orthotopic NSCLC models) both as a single agent and in combination. The PK profile tested in CD-1 mice shows that ML385 has a half-life (t1/2 = 2.82 h) after IP injection (30 mg/kg)[1]. ML385 could alleviate the pancreatic injury[2].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    A549 cells

  • Concentrations

    5 μM

  • Incubation Time

    24, 48 and 72 h

  • Method

    --
Animal Study:

[1]
  • Animal Models

    male CD-1 mice

  • Dosages

    30 mg/kg

  • Administration

    i.p.

Selleck's ML385 has been cited by 121 publications

A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2-TKT pathway [ J Adv Res, 2024, S2090-1232(24)00422-3] PubMed: 39341455
IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1 [ Int J Biol Sci, 2024, 20(6):2323-2338] PubMed: 38617533
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC [ Cell Death Dis, 2024, 15(2):175] PubMed: 38413563
TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway [ Phytomedicine, 2024, 129:155597] PubMed: 38643713
Curcumol ameliorates neuroinflammation after cerebral ischemia-reperfusion injury via affecting microglial polarization and Treg/Th17 balance through Nrf2/HO-1 and NF-κB signaling [ Cell Death Discov, 2024, 10(1):300] PubMed: 38914581
Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway [ Cell Death Discov, 2024, 10(1):35] PubMed: 38238299
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice [ Biol Res, 2024, 57(1):43] PubMed: 38915069
Effect of Urolithin A on the Improvement of Circadian Rhythm Dysregulation in Intestinal Barrier Induced by Inflammation [ Nutrients, 2024, 16(14)2263] PubMed: 39064706
Hydrophobic Components in Light-Yellow Pulp Sweet Potato (Ipomoea batatas (L.) Lam.) Tubers Suppress LPS-Induced Inflammatory Responses in RAW264.7 Cells via Activation of the Nrf2 Pathway [ Nutrients, 2024, 16(4)563] PubMed: 38398887
Downregulation of IL-8 and IL-10 by LRRC8A Inhibition through the NOX2-Nrf2-CEBPB Transcriptional Axis in THP-1-Derived M2 Macrophages [ Int J Mol Sci, 2024, 25(17)9612] PubMed: 39273558

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.