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Technical Data
| Formula | C22 H16 N4 O |
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| Molecular Weight | 352.39 | CAS No. | 1062368-49-3 | |
| Solubility (25°C)* | In vitro | DMSO | 10 mg/mL (28.37 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | ML347 (LDN-193719) is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM. | ||||
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| Targets |
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| In vitro | ML347 also shows potency in BMP-responsive C2C12BRA cells with IC50 of 15 nM, and designated an MLPCN probe. ML347 displays high plasma protein binding in human, rat and mouse plasma. [1] |
Protocol (from reference)
Selleck's ML347 has been cited by 6 publications
| A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression [ Development, 2022, 149(20)dev192310] | PubMed: 35993866 |
| Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors [ Biomolecules, 2020, 10(4)E519] | PubMed: 32235336 |
| Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors. [ Biomolecules, 2020, 29;10(4) pii: E519] | PubMed: 32235336 |
| TGFβ1 Induces Axonal Outgrowth via ALK5/PKA/SMURF1-Mediated Degradation of RhoA and Stabilization of PAR6 [ eNeuro, 2020, 7(5):ENEURO.0104-20.2020] | PubMed: 32887692 |
| Developing a Novel and Convenient Model for Investigating Sweat Gland Morphogenesis from Epidermal Stem Cells [ Stem Cells Int, 2019, 2019:4254759] | PubMed: 30863451 |
| Developing a Novel and Convenient Model for Investigating Sweat Gland Morphogenesis from Epidermal Stem Cells [Tian Hu, et al. Stem Cells International, 2019, 10.1155/2019/4254759] |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.