ML162

Catalog No.S4452 Batch:S445201

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Technical Data

Formula

C23H22Cl2N2O3S
Molecular Weight 477.40 CAS No. 1035072-16-2
Solubility (25°C)* In vitro DMSO 95 mg/mL (198.99 mM)
Ethanol 10 mg/mL (20.94 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO Corn oil
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description ML162 is a covalent inhibitor of cellular phospholipid glutathione peroxidase (GPX-4) that induces ferroptosis.
Targets
GPX-4 [1]
In vitro

ML-162 increases the expression of p62 and Nrf2 in chemoresistant HN3R and HN3-rslR cells, inactivates Keap1, and increases expression of the phospho-PERK ATF4 SESN2 pathway.[2]

Protocol (from reference)

Animal Study:

[3]
  • Animal Models

    Female BALB/c mice

  • Dosages

    40 mg/kg

  • Administration

    i.p.

Selleck's ML162 has been cited by 6 publications

Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila [ Nat Cell Biol, 2024, 10.1038/s41556-024-01450-7] PubMed: 38918597
PRMT6-mediated ADMA promotes p62 phase separation to form a negative feedback loop in ferroptosis [ Theranostics, 2024, 14(10):4090-4106] PubMed: 38994016
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis [ Mol Oncol, 2024, 10.1002/1878-0261.13716] PubMed: 39119789
Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo [ Sci Adv, 2024, 10(7):eadk1835] PubMed: 38354236
ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury [ Int J Mol Sci, 2023, 24(2)1667] PubMed: 36675183
Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy [ Cell Metab, 2022, S1550-4131-2200411-9] PubMed: 36257316

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.