ML-SI3

Catalog No.E0026 Batch:E002601

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Technical Data

Formula

C23H31N3O3S

Molecular Weight 429.58 CAS No. 891016-02-7
Solubility (25°C)* In vitro DMSO 43 mg/mL (100.09 mM)
Ethanol 2 mg/mL (4.65 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description

ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.

Targets
TRPML2 [1] TRPML1 [1]
1.7 μM 4.7 μM
In vitro

ML-SI3 is a potent TRPML channel inhibitor with IC50s of 4.7 µM and 1.7 µM for TRPML1 and TRPML2, respectively.

In vivo

ML-SI3 (1.5 mg/kg, i.p., four times) attenuates I/R injury in mouse cardiomyocytes.

Protocol (from reference)

Animal Study:

[3]

  • Animal Models

    Mice

  • Dosages

    1.5 mg/kg

  • Administration

    i.p.

Selleck's ML-SI3 has been cited by 1 publication

Stress-induced microautophagy is coordinated with lysosome biogenesis and regulated by PIKfyve [ Mol Biol Cell, 2024, 35(5):ar70] PubMed: 38536415

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.