MK6-83

Catalog No.S6947 Batch:S694701

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Technical Data

Formula

C16H20N2O2S2
Molecular Weight 336.47 CAS No. 1062271-24-2
Solubility (25°C)* In vitro DMSO 11 mg/mL (32.69 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description MK6-83 is a novel Transient receptor potential melastatin member 1 (TRPML1) activator that may be used as a potential pharmacological treatment option for a specific subgroup of MLIV patients.
Targets
TRPML1 [1]
In vitro

MK6-83 activates MCOLN1 and triggers cell death of a number of cancer cells by evoking autophagic arrest and subsequent apoptotic response and cell cycle arrest, with little or no effect observed on normal cells.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    HeLa cells, Cos-1 cells, HEK 293 T cells, Patu 8988 t cells, and HPDE6c7 cells

  • Concentrations

    5 μM

  • Incubation Time

    30 min, 90 min, 4 h and 12 h

  • Method

    TFEB activity was not altered following ML-SA5 (1 μM), or ML-SA1 (20 μM), or MK6-83 (5 μM) treatments at 30 min, 90 min, 4 h and 12 h, as assessed by a TFEB-luciferase assay.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.