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Technical Data
| Formula | C24H20ClN3O4 |
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| Molecular Weight | 449.89 | CAS No. | 1394371-71-1 | |
| Solubility (25°C)* | In vitro | DMSO | 90 mg/mL (200.04 mM) | |
| Ethanol | 2 mg/mL (4.44 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | MK-8722 is a potent, direct, allosteric activator of all 12 mammalian pan-AMPK complexes. |
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| Targets |
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| In vitro | MK-8722 activates pAMPK complexes with increased potency and magnitude versus AMP. In primary mouse hepatocytes, HepG2 cells, or primary human myocytes, MK-8722 results in the phosphorylation of a number of additional known targets of pAMPK, and the most potent off-target activity observed for MK8722 is against the serotonin 5-HT2A receptor.[1] |
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| In vivo | Pharmacological pan-AMPK activation by MK-8722 leads to chronically sustainable improvements in glucose homeostasis, including the amelioration of insulin resistance and hyperglycemia. Acute treatment with MK-8722 (30 mpk) significantly suppress blood glucose and insulin levels. In mice, chronic MK-8722 dose also increases muscle Glut4 protein levels. In rhesus monkeys, MK8722 results in cardiac hypertrophy associated with increased cardiac and skeletal muscle glycogen.[1] |
Protocol (from reference)
| Animal Study: |
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Selleck's MK-8722 has been cited by 1 publication
| Opposing roles for AMPK in regulating distinct mitophagy pathways [ Mol Cell, 2024, S1097-2765(24)00865-7] | PubMed: 39532100 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.