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Formula | C18H25N5S2 |
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Molecular Weight | 375.55 | CAS No. | 1271738-62-5 | ||||
Solubility (25°C)* | In vitro | DMSO | 75 mg/mL (199.7 mM) | ||||
Ethanol | 75 mg/mL (199.7 mM) | ||||||
Water | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. | ||
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Targets |
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In vitro | In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations. [1] |
Kinase Assay:[1] |
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Cell Assay:[1] |
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Studies of Epigenetics and Properties of B Cell Receptor in WALDENSTRÖM Macroglobulinemia (WM) [ ProQuest, 2023, 30484965] | PubMed: none |
Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling [ Cell Stem Cell, 2022, S1934-5909(22)00417-9] | PubMed: 36265493 |
Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells [ Life Sci Alliance, 2022, 5(4)e202101187] | PubMed: 35064075 |
Hyperglycemic Memory of Innate Immune Cells Promotes In Vitro Proinflammatory Responses of Human Monocytes and Murine Macrophages [ J Immunol, 2021, ji1901348] | PubMed: 33431659 |
The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer [ Cell Rep, 2019, 26(2):415-428] | PubMed: 30625324 |
Menin Associates with the Mitotic Spindle and is Important for Cell Division [ Endocrinology, 2019, 10.1210/en.2019-00274] | PubMed: 31211356 |
Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer [ Cancer Res, 2018, 78(20):5731-5740] | PubMed: 30135193 |
Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion. [ Front Oncol, 2018, 8:632] | PubMed: 30619766 |
A RUNX2-Mediated Epigenetic Regulation of the Survival of p53 Defective Cancer Cells [ PLoS Genet, 2016, 12(2):e1005884] | PubMed: 26925584 |
Genome-Wide Studies Reveal that H3K4me3 Modification in Bivalent Genes Is Dynamically Regulated during the Pluripotent Cell Cycle and Stabilized upon Differentiation. [Grandy RA, et al. Mol Cell Biol, 2015, 36(4):615-27] | PubMed: 26644406 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.