Resmetirom (MGL-3196)

Catalog No.S6663 Batch:S666302

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Technical Data

Formula

C17H12Cl2N6O4

Molecular Weight 435.22 CAS No. 920509-32-6
Solubility (25°C)* In vitro DMSO 44 mg/mL (101.09 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Resmetirom (MGL-3196, VIA-3196) is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.
Targets
THR-β [1]
(Cell-free assay)
0.21μM(EC50)

Protocol (from reference)

Selleck's Resmetirom (MGL-3196) has been cited by 3 publications

Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner [ Int J Mol Sci, 2023, 24(6)5843] PubMed: 36982915
Resmetirom Ameliorates NASH-Model Mice by Suppressing STAT3 and NF-κB Signaling Pathways in an RGS5-Dependent Manner [ Int J Mol Sci, 2023, 24(6)5843] PubMed: 36982915
A Pyridazinone Compound for Effectively Treating Non-alcoholic Steatohepatitis by Targeting THRβ [ Front Chem, 2022, 10:888587] PubMed: 35620649

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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