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Technical Data
| Formula | C10H8O4 |
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| Molecular Weight | 192.17 | CAS No. | 529-84-0 | |
| Solubility (25°C)* | In vitro | DMSO | 38 mg/mL (197.74 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase (MPO) activity and reduces IL-6 level. | ||
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| Targets |
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| In vitro | ME inhibited hyaluronan (HA) synthesis by human pancreatic cancer cells and weakened their extracellular matrix. It inhibits the adhesion and invasion of cancer cells[1]. |
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| In vivo | ME showed a marked inhibitory effect on the tumor growth of pancreatic cancer in comparison with untreated controls[1]. 4-methylesculetin treatments prevent colonic damage induced by trinitrobenzenesulphonic acid (TNBS) in rats. This effect can be attributed to its antioxidant and anti-inflammatory properties[2]. |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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