Methyl salicylate

Catalog No.S3756 Batch:S375601

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Technical Data

Formula

C8H8O3
Molecular Weight 152.15 CAS No. 119-36-8
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Methyl salicylate (Betula oil, Gaultheria oil, Methyl 2-hydroxybenzoate, Natural wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. It is an agonist for TRPA1 and TRPV1.
Targets
TRPA1 [1]
(Cell-free assay)		 TRPV1 [1]
(Cell-free assay)
In vitro In human embryonic kidney 293 cells expressing human TRPV1 (hTRPV1), Methyl salicylate evokes increases of [Ca2+]i, which declines regardless of its continuous presence, indicative of marked desensitization. Methyl salicylate promotes Ca2+ influx through the activation of TRPV1 channels and reversibly inhibits hTRPV1 activation by polymodal stimuli such as capsaicin, protons, heat, anandamide, and 2-aminoethoxydiphenyl borate. Methyl salicylate is an effective agonist for recombinant human and porcine TRPV1[1].
In vivo Methyl salicylate significantly suppresses nocifensive behavior induced by intraplantar capsaicin in rats[1].
Density 1.174 g/mL at 25 °C

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    HEK 293 cells

  • Concentrations

    3 mM

  • Incubation Time

    --

  • Method

    Fura-2-loaded hTRPV1-expressing HEK 293 cells are first stimulated with capsaicin (30 nM) and subsequently with Methyl salicylate (3 mM).
Animal Study:[1]
  • Animal Models

    Male Wistar rats (8 weeks old)

  • Dosages

    0.5 mg

  • Administration

    injected into the same hind paw

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.