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Formula | C4H11N5 |
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Molecular Weight | 129.16 | CAS No. | 657-24-9 | |
Solubility (25°C)* | In vitro | DMSO | 26 mg/mL (201.3 mM) | |
Water | 26 mg/mL (201.3 mM) | |||
Ethanol | 13 mg/mL (100.65 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Metformin (1,1-Dimethylbiguanide), a widely used drug for treatment of type 2 diabetes, activates AMP-activated protein kinase (AMPK) in hepatocytes. Metformin promotes mitophagy in mononuclear cells. Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. | |||
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In vitro | Metformin upregulates BAX activation with facilitation of BIM, BAD and PUMA, downregulates Bcl-2 and Bcl-xl, also induces cytochrome c release from mitochondria into the cytoplasm, directly triggering caspase-9-mediated mitochondrial apoptosis.[4] |
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In vivo | Metformin shows therapeutic effect of metformin in mouse model of liver fibrosis associated with nonalcoholic steatohepatitis (NASH) in which hepatic function, NASH lesions and fibrosis are improved.[4] |
Cell Assay: |
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Animal Study: |
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Pump-Less, Recirculating Organ-On-Chip (rOoC) Platform To Model The Metabolic Crosstalk Between Islets and Liver [ Adv Healthc Mater, 2024, e2303785.] | PubMed: 38221504 |
Multivariate analysis of metabolic state vulnerabilities across diverse cancer contexts reveals synthetically lethal associations [ Cell Rep, 2024, 43(10):114775] | PubMed: 39305483 |
Metformin enhances endogenous neural stem cells proliferation, neuronal differentiation, and inhibits ferroptosis through activating AMPK pathway after spinal cord injury [ J Transl Med, 2024, 22(1):723] | PubMed: 39103875 |
Adenosine kinase protects against acetaminophen-induced acute liver injury by activating autophagy in hepatocytes [ Cell Biol Toxicol, 2024, 40(1):59] | PubMed: 39060559 |
Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis [ CNS Neurosci Ther, 2024, 30(8):e14913] | PubMed: 39123294 |
Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis [ CNS Neurosci Ther, 2024, 30(8):e14913] | PubMed: 39123294 |
Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis [ J Biol Chem, 2024, 300(8):107542] | PubMed: 38992436 |
Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites [ Oncol Res, 2024, 32(10):1637-1648] | PubMed: 39308524 |
Evolution of transcriptomic profiles in relapsed inv(16) acute myeloid leukemia [ Leuk Res, 2024, 145:107568] | PubMed: 39180902 |
A novel direct adenosine monophosphate kinase activator ameliorates disease progression in preclinical models of Autosomal Dominant Polycystic Kidney Disease [ Kidney Int, 2023, 103(5):917-929] | PubMed: 36804411 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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