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Technical Data
| Formula | C20H10Br2HgO6.2Na |
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| Molecular Weight | 752.68 | CAS No. | 129-16-8 | |
| Solubility (25°C)* | In vitro | Water | 100 mg/mL (132.85 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Merbromin (Mercurochrome), a xanthene dye and an antibacterial agent, is the first of a series of antiseptics that contained mercury, also is a mixed-type inhibitor of 3CLpro due to its ability of increasing the KM and decreasing the Kcat of 3CLpro. | ||
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| Targets |
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| In vitro | Merbromin strongly inhibites the proteolytic activity of 3CLpro which is a promising target for developing anti-SARS-CoV-2 drugs. Michaelis-Menten kinetic analysis shows that Merbromin is a mixed-type inhibitor of 3CLpro, indicating by its ability of increasing the KM and decreasing the Kcat of 3CLpro. And 3CLpro possessed two binding sites for Merbromin.[2] |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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