Mefenamic Acid

Catalog No.S4078 Batch:S407801

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Technical Data

Formula

C15H15NO2
Molecular Weight 241.29 CAS No. 61-68-7
Solubility (25°C)* In vitro DMSO 48 mg/mL (198.93 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 10% PEG 300 5%Tween80 80%ddH2O
0.5mg/ml Taking the 1 mL working solution as an example, add 50 μL of 10 mg/ml clarified DMSO stock solution to 100 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 800 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
1.25mg/ml Taking the 1 mL working solution as an example, add 50 μL of 25 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Mefenamic Acid (CI 473, CN-35355) is a competitive inhibitor of COX-1 and COX-2.
Targets
COX-1 [1] COX-2 [1]

Protocol (from reference)

Selleck's Mefenamic Acid has been cited by 3 publications

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma [ J Immunother Cancer, 2024, 12(11)e009805] PubMed: 39581704
KV7.1 channel blockade inhibits neonatal renal autoregulation triggered by a step decrease in arterial pressure [ Am J Physiol Renal Physiol, 2022, 10.1152/ajprenal.00568.2020] PubMed: 35001664
Mefenamic Acid Can Attenuate Depressive Symptoms by Suppressing Microglia Activation Induced Upon Chronic Stress [ Brain Res, 2020, 20;1740:146846] PubMed: 32325074

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.