Mechlorethamine HCl

Catalog No.S4252 Batch:S425201

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Technical Data

Formula

C5H11Cl2N.HCl
Molecular Weight 192.51 CAS No. 55-86-7
Solubility (25°C)* In vitro DMSO 39 mg/mL (202.58 mM)
Water 39 mg/mL (202.58 mM)
Ethanol 39 mg/mL (202.58 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Mechlorethamine is the prototype of alkylating agents, it works by binding to DNA, crosslinking two strands and preventing cell duplication.
Targets
DNA synthesis [1]
In vitro Mechlorethamine is much less toxic to rat hepatocytes under nitrogen and causes much less lipid peroxidation than under aerobic conditions. [1] Mechlorethamine markedly inhibits cell growth and leads to cell detachment associated with rearrangement of the cytoskeletal proteins in rabbit tracheal primary cultures. Mechlorethamine results in early lipid peroxidation and cellular membrane damage in rabbit tracheal primary cultures, this is correlated with a significant increase in the activities of antioxidant enzymes associated with an increase in glutathione content. [2]
In vivo Mechlorethamine (1.5 mg/kg i.v.) reduces mean leukocyte count from 6,320 mm3 to 1,890 mm3 without any change in the leukocyte differential or erythrocyte and platelet counts in rabbits. [3] Mechlorethamine (0.005 mg-0.5 mg, i.d.) causes dose-dependent skin ulcers in the mouse, and isotonic sodium thiosulfate (0.167 M) or hypertonic (0.34 M) (0.05 mL) given immediately after Mechlorethamine significantly reduces the mean HN2 ulceration area and the total time of ulceration. [4]

Protocol (from reference)

Selleck's Mechlorethamine HCl has been cited by 5 publications

TRPS1 drives heterochromatic origin refiring and cancer genome evolution [ Cell Rep, 2021, 34(10):108814] PubMed: 33691114
Establishment and characterization of patient-derived cancer models of malignant peripheral nerve sheath tumors. [ Cancer Cell Int, 2020, 19;20:58] PubMed: 32099531
Establishment and characterization of NCC-MFS2-C1: a novel patient-derived cancer cell line of myxofibrosarcoma [ Hum Cell, 2020, 10.1007/s13577-020-00420-z] PubMed: 32870449
Establishment and characterization of a novel cell line, NCC-TGCT1-C1, derived from a patient with tenosynovial giant cell tumor [ Hum Cell, 2020, 10.1007/s13577-020-00425-8] PubMed: 32886306
Nitrogen Mustard Induces Formation of DNA-Histone Cross-Links in Nucleosome Core Particles. [ Chem Res Toxicol, 2019, 32(12):2517-2525] PubMed: 31726825

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.