Mebendazole

Catalog No.S4610 Batch:S461001

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Technical Data

Formula

C16H13N3O3
Molecular Weight 295.29 CAS No. 31431-39-7
Solubility (25°C)* In vitro DMSO 6 mg/mL warmed with 50ºC water bath (20.31 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Mebendazole is a synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake.
In vitro mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines. MZ arrests cells at the G2-M phase before the onset of apoptosis. MZ treatment also results in mitochondrial cytochrome c release, followed by apoptotic cell death. Additionally, MZ appears to be a potent inhibitor of tumor cell growth with little toxicity to normal WI38 and human umbilical vein endothelial cells[2].
In vivo When administered p.o. to nu/nu mice, MZ strongly inhibits the growth of human tumor xenografts and significantly reduces the number and size of tumors in an experimental model of lung metastasis. MZ treatment significantly reduces vessel densities in mice compared with those in control mice[2].

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    A549, WI38 normal fibroblasts, H1299 and H460 cancer cell line

  • Concentrations

    0, 0.2, 0.5, 1 μM

  • Incubation Time

    48 h

  • Method

    When grown to 40–50% confluence, the cells are exposed to MZ dissolved in DMSO. Cell growth is monitored by counting the viable cells using a hemacytometer.
Animal Study:[1]
  • Animal Models

    Mice

  • Dosages

    12.5 and 25 mg/kg/day

  • Administration

    oral administration

Selleck's Mebendazole has been cited by 7 publications

Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma [ Cancers (Basel), 2022, 14(17)4196] PubMed: 36077733
Mebendazole Impedes the Proliferation and Migration of Pancreatic Cancer Cells through SK1 Inhibition Dependent Pathway [ Molecules, 2022, 27(23)8127] PubMed: 36500220
TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells [ Adv Biol (Weinh), 2022, 6(8):e2200030] PubMed: 35675910
The genomic architecture of EBV and infected gastric tissue from precursor lesions to carcinoma [ Genome Med, 2021, 13(1):146] PubMed: 34493320
Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways [ Aging (Albany NY), 2021, 13(13):17407-17427] PubMed: 34232919
AMXI-5001, a novel dual parp1/2 and microtubule polymerization inhibitor for the treatment of human cancers [ Am J Cancer Res, 2020, 10(8):2649-2676] PubMed: 32905466
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis. [ J Biol Chem, 2019, 10.1074/jbc.RA119.010144] PubMed: 31628193

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.