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Formula | C20H23N2O5S.Na |
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Molecular Weight | 426.46 | CAS No. | 256373-96-3 | ||||
Solubility (25°C)* | In vitro | Water | 43 mg/mL (100.83 mM) | ||||
Ethanol | 43 mg/mL (100.83 mM) | ||||||
DMSO | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | MCC950 Sodium is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs; but not the AIM2, NLRC4 or NLRP1 inflammasomes. | ||||
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In vitro | MCC950 inhibits canonical and noncanonical NLRP3 activation in BMDM and HMDM cells at IC50 of 7.5 and 8.1nM. MCC950 specifically inhibits activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes.[1] |
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In vivo | MCC950 reduces interleukin-1β (IL-1β) production and attenuates the severity of experimental autoimmune encephalomyelitis (EAE). Furthermore, MCC950 treatment rescues neonatal lethality in a mouse model of CAPS and is active in ex vivo samples from individuals with Muckle-Wells syndrome. [1] |
Cell Assay: |
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Animal Study: |
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Data from [Data independently produced by , , ARTHRITIS & RHEUMATOLOGY, 2017, 69(8):1636-1646]
Data from [Data independently produced by , , Biochem Pharmacol, 2018, 154:278-292]
Data from [Data independently produced by , , Biochem Biophys Res Commun, 2018, 503(4):3031-3037]
Data from [Data independently produced by , , BMC Complement Altern Med, 2018, 18(1):192]
Experimental TET2 Clonal Hematopoiesis Predisposes to Renal Hypertension Through an Inflammasome-Mediated Mechanism [ Circ Res, 2024, 135(9):933-950] | PubMed: 39234670 |
P2X7R Modulates NEK7-NLRP3 Interaction to Exacerbate Experimental Autoimmune Prostatitis via GSDMD-mediated Prostate Epithelial Cell Pyroptosis [ Int J Biol Sci, 2024, 20(9):3393-3411] | PubMed: 38993566 |
YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3 [ Cell Death Dis, 2024, 15(5):360] | PubMed: 38789414 |
Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells [ Cell Rep, 2024, 43(3):113954] | PubMed: 38492221 |
A stress sensor, IRE1α, is required for bacterial-exotoxin-induced interleukin-1β production in tissue-resident macrophages [ Cell Rep, 2024, 43(4):113981] | PubMed: 38520688 |
RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis [ PLoS Pathog, 2024, 20(8):e1012387] | PubMed: 39213434 |
UCP2 knockout exacerbates sepsis-induced intestinal injury by promoting NLRP3-mediated pyroptosis [ Int Immunopharmacol, 2024, 141:112935] | PubMed: 39159561 |
sTREM2 Differentially Affects Cytokine Expression in Myeloid-Derived Cell Models via MAPK-JNK Signaling Pathway [ Biology (Basel), 2024, 13(2)87] | PubMed: 38392305 |
Force-induced Caspase-1-dependent pyroptosis regulates orthodontic tooth movement [ Int J Oral Sci, 2024, 16(1):3] | PubMed: 38221531 |
The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication [ bioRxiv, 2024, 2024.03.27.586885] | PubMed: 38585846 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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